Background: Chalcones are structurally simple compounds that are easily accessible by synthetic
methods. Heterocyclic chalcones have gained the interest of scientists due to their diverse biological activities.
The anti-tumor activities of heterocyclic chalcones are especially remarkable and the growing number of publications
dealing with this topic warrants an up-to-date compilation.
Methods: Search for antitumor active heterocyclic chalcones was carried out using Pubmed and Scifinder as
common web-based literature searching tools. Pertinent and current literature was covered from 2015/2016 to
2019. Chemical structures, biological activities and modes of action of anti-tumor active heterocyclic chalcones
Results: Simply prepared chalcones have emerged over the last years with promising antitumor activities.
Among them, there are a considerable number of tubulin polymerization inhibitors. But there are also new chalcones
targeting special enzymes such as histone deacetylases or with DNA-binding properties.
Conclusion: This review provides a summary of recent heterocyclic chalcone derivatives with distinct antitumor