Background: The aim of the present review is to provide basic knowledge about the treatment of Coronavirus via
medicinal plants. Coronavirus (COVID-19, SARS-CoV, and MERS-CoV) as a viral pneumonia causative agent, infects
thousands of people in China and worldwide. There is currently no specific medicine or vaccine available and it is considered a threat to develop effective novel drug or anti-coronavirus vaccine treatment. However, natural compounds to treat
coronaviruses are the most alternative and complementary therapies due to their diverse range of biological and therapeutic
Methods: We performed an open-ended, English restricted search of Scopus database, Web of Science, and Pubmed for all
available literature from Jan-March, 2020, using terms related to phytochemical compounds, medicinal plants and coronavirus.
Results: The view on anti-coronavirus (anti-CoV) activity in the plant derived phytochemicals and medicinal plants give the
strong base to develop a novel treatment of corona virus activity. Various phytochemicals and medicinal plant extracts have
been revised and considered to be the potential anti-CoV agents for effective control and future drug development. We discuss some important plants (Scutellaria baicalensis, Psorothamnus arborescens, Glycyrrhiza radix, Glycyrrhiza uralensis ,
Lycoris radiate, Phyllanthus emblica, Camellia sinensis, Hyptis atrorubens Poit, Fraxinus sieboldiana, Erigeron breviscapus, Citri Reticulatae Pericarpium, Amaranthus tricolor, Phaseolus vulgaris, Rheum palmatum, Curcuma longa and Myrica cerifera) emerged to have broad spectrum antiviral activity.
Conclusion: Nigella sativa has potent anti-SARS-CoV activity and it might be useful souce for developing novel antiviral
therapies for coronaviruses.