Leishmaniasis is a neglected disease that affects 15 million people worldwide. Existing treatments are
associated with limitations, including high costs and toxicity. Several classes of natural substances have been reported
to display leishmanicidal activity in the literature. Isoquinoline alkaloids, which are commonly found in the
Annonaceae family, represent an important skeleton for the development of anti-leishmaniasis products. This study
presents an overview of the potential use of Annonaceae alkaloids to treat leishmaniasis and describes a molecular
docking study examining 215 isoquinoline alkaloids. All selected compounds contain a bisbenzyltetrahydroisoquinoline,
suggesting the affinity of this skeleton for the target.
Keywords: Annonaceae, alkaloids, isoquinoline, leishmaniasis, Leishmania donovani, neglected diseases, docking, N-myristoyltransferase.
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