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ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

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Mini-Review Article

Experimental and Clinical Evidence of Endothelial Dysfunction in Inflammatory Bowel Disease

Author(s): Mariana Ferreira-Duarte, Joana Beatriz Sousa, Carmen Diniz, Teresa Sousa, Margarida Duarte-Araújo and Manuela Morato*

Volume 26, Issue 30, 2020

Page: [3733 - 3747] Pages: 15

DOI: 10.2174/1381612826666200701212414

Price: $65

Abstract

The endothelium has a crucial role in proper hemodynamics. Inflammatory bowel disease (IBD) is mainly a chronic inflammatory condition of the gastrointestinal tract. However, considerable evidence points to high cardiovascular risk in patients with IBD. This review positions the basic mechanisms of endothelial dysfunction in the IBD setting (both clinical and experimental). Furthermore, we review the main effects of drugs used to treat IBD in endothelial (dys)function. Moreover, we leave challenging points for enlarging the therapeutic arsenal for IBD with new or repurposed drugs that target endothelial dysfunction besides inflammation.

Keywords: Inflammatory Bowel Disease, endothelium dysfunction, experimental and clinical studies, hemodynamics, cardiovascular, IBD.

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