Matrix Metalloproteinases (MMPs), as a family of zinc-containing enzymes, show the function
of decomposing Extracellular Matrix (ECM) and participate in the physiological processes of cell
migration, growth, inflammation, and metabolism. Clinical and experimental studies have indicated
that MMPs play an essential role in tissue injury and repair as well as tumor diagnosis, metastasis, and
prognosis. An increasing number of researchers have paid attention to their functions and mechanisms
in bone health and diseases. The present review focuses on MMPs-inspired therapeutic strategies for
the treatment of bone-related diseases. We introduce the role of MMPs in bone diseases, highlight the
MMPs-inspired therapeutic options, and posit MMPs as a trigger for smart cell/drug delivery.