Aims: The study aimed to investigate the antihyperglycemic activity of Matricaria
Background: Matricaria pubescens (Def). Shultz (Asteraceae) is commonly used traditionally for
the treatment of diabetes in Morocco.
Objective: The present investigation aimed to assess the antihyperglycemic and antioxidant effects
of the aqueous extract of the aerial part of Matricaria pubescens (M. pubescens).
Methods: The effect of a single and repeated oral administration of the aqueous extract of aerial
part of M. pubescens (AEAPMP) at a dose of 40 mg/kg on glucose was examined in normal and
streptozotocin-induced diabetic rats. Additionally, histopathological examination of the pancreas
and liver was carried out according to the Hematoxylin-Eosin method. The antioxidant activity was
performed using the DPPH assay.
Results: The results showed that the aqueous extract of M. pubescens (AEAPMP) exhibited a significant
lowering activity on blood glucose levels in STZ-induced diabetic rats. In addition,
AEAPMP ameliorated the histopathological tissues of the liver and pancreas. Furthermore, in vitro
antioxidant activity of AEAPMP has been shown.
Conclusion: In conclusion, this study demonstrates that M. pubescens possesses a beneficial effect
against hyperglycemia associated with diabetes.