Title:Antihyperglycemic Potential of Matricaria pubescens (Desf.) Schultz. in Streptozotocin-induced Diabetic Rats
VOLUME: 20 ISSUE: 4
Author(s):Ayoub Amssayef, Mohammed Ajebli and Mohamed Eddouks*
Affiliation:Team of Ethnopharmacology and Pharmacognosy, Faculty of Sciences and Techniques Errachidia, Moulay Ismail University of Meknes, BP 509, Boutalamine, 52000, Errachidia, Team of Ethnopharmacology and Pharmacognosy, Faculty of Sciences and Techniques Errachidia, Moulay Ismail University of Meknes, BP 509, Boutalamine, 52000, Errachidia, Team of Ethnopharmacology and Pharmacognosy, Faculty of Sciences and Techniques Errachidia, Moulay Ismail University of Meknes, BP 509, Boutalamine, 52000, Errachidia
Keywords:Antihyperglycemic, Matricaria pubescens, histopathology, streptozotocin, aqueous extract, antioxidant.
Abstract:
Aims: The study aimed to investigate the antihyperglycemic activity of Matricaria
pubescens.
Background: Matricaria pubescens (Def). Shultz (Asteraceae) is commonly used traditionally for
the treatment of diabetes in Morocco.
Objective: The present investigation aimed to assess the antihyperglycemic and antioxidant effects
of the aqueous extract of the aerial part of Matricaria pubescens (M. pubescens).
Methods: The effect of a single and repeated oral administration of the aqueous extract of aerial
part of M. pubescens (AEAPMP) at a dose of 40 mg/kg on glucose was examined in normal and
streptozotocin-induced diabetic rats. Additionally, histopathological examination of the pancreas
and liver was carried out according to the Hematoxylin-Eosin method. The antioxidant activity was
performed using the DPPH assay.
Results: The results showed that the aqueous extract of M. pubescens (AEAPMP) exhibited a significant
lowering activity on blood glucose levels in STZ-induced diabetic rats. In addition,
AEAPMP ameliorated the histopathological tissues of the liver and pancreas. Furthermore, in vitro
antioxidant activity of AEAPMP has been shown.
Conclusion: In conclusion, this study demonstrates that M. pubescens possesses a beneficial effect
against hyperglycemia associated with diabetes.
