Antihyperglycemic Potential of Matricaria pubescens (Desf.) Schultz. in Streptozotocin-induced Diabetic Rats

Author(s): Ayoub Amssayef, Mohammed Ajebli, Mohamed Eddouks*

Journal Name: Cardiovascular & Hematological Disorders-Drug Targets
Formerly Current Drug Targets - Cardiovascular & Hematological Disorders

Volume 20 , Issue 4 , 2020


DOI : 10.2174/1871529X20666200630112610

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Graphical Abstract:


Abstract:

Aims: The study aimed to investigate the antihyperglycemic activity of Matricaria pubescens.

Background: Matricaria pubescens (Def). Shultz (Asteraceae) is commonly used traditionally for the treatment of diabetes in Morocco.

Objective: The present investigation aimed to assess the antihyperglycemic and antioxidant effects of the aqueous extract of the aerial part of Matricaria pubescens (M. pubescens).

Methods: The effect of a single and repeated oral administration of the aqueous extract of aerial part of M. pubescens (AEAPMP) at a dose of 40 mg/kg on glucose was examined in normal and streptozotocin-induced diabetic rats. Additionally, histopathological examination of the pancreas and liver was carried out according to the Hematoxylin-Eosin method. The antioxidant activity was performed using the DPPH assay.

Results: The results showed that the aqueous extract of M. pubescens (AEAPMP) exhibited a significant lowering activity on blood glucose levels in STZ-induced diabetic rats. In addition, AEAPMP ameliorated the histopathological tissues of the liver and pancreas. Furthermore, in vitro antioxidant activity of AEAPMP has been shown.

Conclusion: In conclusion, this study demonstrates that M. pubescens possesses a beneficial effect against hyperglycemia associated with diabetes.

Keywords: Antihyperglycemic, Matricaria pubescens, histopathology, streptozotocin, aqueous extract, antioxidant.

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Article Details

VOLUME: 20
ISSUE: 4
Year: 2020
Page: [297 - 304]
Pages: 8
DOI: 10.2174/1871529X20666200630112610
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