Background: As one of the most commonly diagnosed cancers among men and women,
Colorectal Cancer (CRC) leads to high rates of morbidity and mortality across the globe. Recent anti-
CRC therapies are now targeting specific signaling pathways involved in colorectal carcinogenesis.
Ubiquitin Proteasome System (UPS) and autophagy are two main protein quality control systems,
which play major roles in the carcinogenesis of colorectal cancer. A balanced function of these
two pathways is necessary for the regulation of cell proliferation and cell death.
Objective: In this systematic review, we discuss the available evidence regarding the roles of autophagy
and ubiquitination in progression and inhibition of CRC.
Methods: The search terms “colorectal cancer” or “colon cancer” or “colorectal carcinoma” or
“colon carcinoma” in combination with “ubiquitin proteasome” and “autophagy” were searched in
PubMed, Web of Science, and Scopus databases, and also Google Patents (https://patents.google
.com) from January 2000 to Feb 2020.
Results: The most important factors involved in UPS and autophagy have been investigated. There
are many important factors involved in UPS and autophagy but this systematic review shows the
studies that have mostly focused on the role of ATG, 20s proteasome and mTOR in CRC, and the
more important factors such as ATG8, FIP200, and TIGAR factors that are effective in the regulation
of autophagy in CRC cells have not been yet investigated.
Conclusion: The most important factors involved in UPS and autophagy such as ATG, 20s proteasome
and mTOR, ATG8, FIP200, and TIGAR can be considered in drug therapy for controlling or