Progress in [18F]Fluorination by Using Aryliodonium(III) Compounds and Application for PET Tracer Syntheses

Author(s): Kotaro Kikushima*, Ravi Kumar, Toshifumi Dohi*

Journal Name: Mini-Reviews in Organic Chemistry

Volume 18 , Issue 2 , 2021

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Graphical Abstract:


[18F]-labeled drugs and radioligands are most frequently used in positron-emission tomography (PET) radiopharmaceuticals for both clinical and preclinical research. Various methods for the introduction of [18F]fluorine into complex molecules through fluorination reactions have been reported. Herein, recent advances in [18F]-fluorination utilizing aryliodonium(III) compounds are highlighted.

Keywords: [18F]fluorine, aryliodonium compound, fluoroarene, late-stage fluorination, PET imaging, radiosynthesis.

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Article Details

Year: 2021
Published on: 29 June, 2020
Page: [173 - 196]
Pages: 24
DOI: 10.2174/1570193X17999200629155733
Price: $65

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PDF: 20