Background: Psoriasis is an autoimmune disease of the skin with lapsing episodes of hyperkeratosis,
irritation, and inflammation. Numerous traditional and novel drug delivery systems
have been used for better penetration through psoriatic barrier cells and also for retention in the
skin. As there is no effective remedy for better penetration, and retention is there because of the
absence of an ideal carrier for effective and safe delivery of antipsoriatic drugs.
Objectives: The main objective of this project is to develop a Squalene integrated NLC based carbopol
940 gel to create a local drug depot in the skin for improved efficacy against psoriasis.
Methods: Homogenization method is used for the formulation of Nanostructured Lipid Carrier,
which was characterized on the basis of size, entrapment efficiency, polydispersity index (PDI), viscosity,
spreadability, DSC, zeta potential, % in vitro release, in vitro skin permeation and retention
studies, physical storage stability studies. In vivo studies can use other alternative models for induction
of psoriasis by severe redness, swelling macroscopically, and microvascular dilation edema
lasting for 10 days. Furthermore, histopathology study was done to asses changes in the skin.
Conclusion: The optimized formulation of nanostructured lipid carrier-based gel has shown significant
and sustained release of clobetasol propionate. Furthermore, this formulation has also shown
retention in skin because of squalene as it is a sebum derived lipid, which shows an affinity towards
the sebaceous gland.