Immunosuppressive Therapy in Lung Transplantation

Author(s): Juan C. Fernandez-Castillo, Marcelo Cypel*

Journal Name: Current Pharmaceutical Design

Volume 26 , Issue 28 , 2020

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Long term survival and quality of life after lung transplantation are still affected by the development of chronic lung graft dysfunction (CLAD). CLAD is the number one cause of death one year after transplant; and there is no effective therapy available to date. Transplant centers’ approaches include perioperative immunosuppression, maintenance immunosuppression, and the treatment of eventual rejection. This review will focus on maintenance immunosuppression and the available data that support these strategies, as well as a brief description of our desensitization protocol and immunologic risk stratification. Optimization of immunosuppression is key to increase survival and graft function in transplant recipients, mostly through the combination of drugs. Since the therapeutic options to manage CLAD are still very limited, more studies are necessary to test new therapies and to clarify the potential role of new agents.

Keywords: Lung transplantation, chronic lung graft dysfunction, review, immunosuppression, risk stratification, transplant.

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Article Details

Year: 2020
Published on: 30 August, 2020
Page: [3385 - 3388]
Pages: 4
DOI: 10.2174/1381612826666200628023150
Price: $65

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