Development of New Therapeutics to Meet the Current Challenge of Drug Resistant Tuberculosis

(E-pub Ahead of Print)

Author(s): Bashir A Sheikh, Basharat A Bhat, Umar Mehraj, Wajahat Mir, Suhail Hamadani, Manzoor A Mir*

Journal Name: Current Pharmaceutical Biotechnology

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Abstract:

Tuberculosis (TB) is a prominent infective disease and a major reason of mortality/morbidity globally. Mycobacterium tuberculosis causes a long-lasting latent infection in a significant proportion of human population. The increasing burden of tuberculosis is mainly caused due to drug and multi drug-resistant. The failure of conventional treatment has been observed in large number of cases. Drugs that are used to treat extensively drug-resistant tuberculosis are expensive, have limited efficacy and with more side effects for longer duration of time and is often associated with poor prognosis. To regulate the emergence of multidrug resistant tuberculosis, extensively drug-resistant tuberculosis and totally drug resistant” tuberculosis, efforts are being made to understand the genetic/molecular basis of target drug delivery and mechanisms of drug resistance. Understanding the molecular approaches and pathology of Mycobacterium tuberculosis through whole genome sequencing may further help for the improvement of new therapeutics to meet the current challenge of global health. Understanding cellular mechanisms that trigger resistance to Mycobacterium tuberculosis infection may expose immune associates of protection which could be an important way for vaccine development, diagnostics and novel host-directed therapeutic strategies. Recent development of new drugs and combinational therapies for drugresistant tuberculosis through major collaboration between industry, donors and academia gives an improved hope to overcome the challenges in tuberculosis treatment. In this review article, we will try to high-light the new developments of drug resistance to the conventional drugs and the recent progress in the development of new therapeutics for the treatment of drug resistant and non-resistant cases.

Keywords: tuberculosis, multidrug resistant TB, gene mutations, drug targets, extensively drug resistant TB (XDR-TB), totally drug resistant TB (TDR-TB)

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