The Relationship between Social Cognition and Executive Functions in Alzheimer’s Disease: A Systematic Review

Author(s): Tatiana T.B.A. dos Santos*, Raquel L.S. de Carvalho, Marcela Nogueira, Maria A.T. Baptista, Nathália Kimura, Isabel B. Lacerda, Marcia C.N. Dourado

Journal Name: Current Alzheimer Research

Volume 17 , Issue 5 , 2020


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Abstract:

Introduction: Social Cognition (SC) is a complex construct that reflects a wide variety of implicit and explicit cognitive processes. Many neurocognitive domains are associated with SC and the Executive Function (EF) is the most representative one. We conducted a systematic review aiming at clarifying whether SC impairments are associated with dysfunction on EF in people with Alzheimer Disease (AD).

Methods: The search, based on the Preferred Reporting Items for Systematic Reviews and Meta- Analyses (PRISMA), was undertaken between January 2007 and December 2019 using Pubmed, SciELO, BIREME and Thomson Reuters Web of Science electronic databases. The keywords were SC, AD, EF, Neuropsychological functioning and Executive Disorder.

Results: One hundred thirty-six articles were identified and fifteen were included. These studies are not in agreement about the extent of SC deficits in AD, mainly in the mild stage of the disease. EF deficits, specifically inhibition and the ability to manipulate verbal information, are associated with the impairment in SC in AD. SC decreases with the disease progression, a relationship explained by global cognition impairment and SC specific symptoms.

Conclusion: SC impairment is associated with disease progression, mainly because of the decline in EF. Studies on SC components are unequal, contributing to a frequent generalization of Theory of Mind results, and often hampering the investigation of other components, mainly empathy. More precise knowledge about SC functioning in AD may contribute to a better understanding of the behavioral changes and interpersonal interactions.

Keywords: Theory of mind, emotion recognition, empathy, cognition, executive functions, Alzheimer`s disease.

[1]
Beer JS, Ochsner KN. Social cognition: A multi level analysis. Brain Res 2006; 1079(1): 98-105.
[http://dx.doi.org/10.1016/j.brainres.2006.01.002] [PMID: 16513097]
[2]
Henry JD, von Hippel W, Molenberghs P, Lee T, Sachdev PS. Clinical assessment of social cognitive function in neurological disorders. Nat Rev Neurol 2016; 12(1): 28-39.
[http://dx.doi.org/10.1038/nrneurol.2015.229] [PMID: 26670297]
[3]
Belfort T, Simões P, de Sousa MFB, et al. The relationship between social cognition and awareness in Alzheimer disease. J Geriatr Psychiatry Neurol 2018; 31(1): 27-33.
[http://dx.doi.org/10.1177/0891988717743587] [PMID: 29187026]
[4]
Harciarek M, Cosentino S. Language, executive function and social cognition in the diagnosis of frontotemporal dementia syndromes. Int Rev Psychiatry 2013; 25(2): 178-96.
[http://dx.doi.org/10.3109/09540261.2013.763340] [PMID: 23611348]
[5]
Shany-Ur T, Rankin KP. Personality and social cognition in neurodegenerative disease. Curr Opin Neurol 2011; 24(6): 550-5.
[http://dx.doi.org/10.1097/WCO.0b013e32834cd42a] [PMID: 22002077]
[6]
Adolphs R. Social cognition and the human brain. Trends Cogn Sci(Regul Ed) 1999; 3(12): 469-79.
[http://dx.doi.org/10.1016/S1364-6613(99)01399-6] [PMID: 10562726]
[7]
Adolphs R. The social brain: Neural basis of social knowledge. Annu Rev Psychol 2009; 60: 693-716.
[http://dx.doi.org/10.1146/annurev.psych.60.110707.163514] [PMID: 18771388]
[8]
Kumfor F, Honan C, McDonald S, Hazelton JL, Hodges JR, Piguet O. Assessing the “social brain” in dementia: Applying TASIT-S. Cortex 2017; 93: 166-77.
[http://dx.doi.org/10.1016/j.cortex.2017.05.022] [PMID: 28662418]
[9]
Suchy Y. Executive functioning: Overview, assessment, and research issues for non-neuropsychologists. Ann Behav Med 2009; 37(2): 106-16.
[http://dx.doi.org/10.1007/s12160-009-9097-4] [PMID: 19455377]
[10]
Blakemore SJ, Choudhury S. Development of the adolescent brain: Implications for executive function and social cognition. J Child Psychol Psychiatry 2006; 47(3-4): 296-312.
[http://dx.doi.org/10.1111/j.1469-7610.2006.01611.x] [PMID: 16492261]
[11]
Zelazo P, Cunningham W. Executive functions: Mechanisms underlying emotion regulation. Handbook of emotion regulation In: New York. Guilford 2007; pp. 135-58.
[12]
Gyurak A, Goodkind MS, Kramer JH, Miller BL, Levenson RW. Executive functions and the down-regulation and up-regulation of emotion. Cogn Emotion 2012; 26(1): 103-18.
[http://dx.doi.org/10.1080/02699931.2011.557291] [PMID: 21432634]
[13]
Miyake A, Friedman NP, Emerson MJ, Witzki AH, Howerter A, Wager TD. The unity and diversity of executive functions and their contributions to complex “Frontal Lobe” tasks: A latent variable analysis. Cognit Psychol 2000; 41(1): 49-100.
[http://dx.doi.org/10.1006/cogp.1999.0734] [PMID: 10945922]
[14]
Diamond A. Executive functions. Annu Rev Psychol 2013; 64: 135-68.
[http://dx.doi.org/10.1146/annurev-psych-113011-143750] [PMID: 23020641]
[15]
Hutchings R, Palermo R, Piguet O, Kumfor F. Disrupted face processing in frontotemporal dementia: A review of the clinical and neuroanatomical evidence. Neuropsychol Rev 2017; 27(1): 18-30.
[http://dx.doi.org/10.1007/s11065-016-9340-2] [PMID: 28116580]
[16]
Bediou B, Ryff I, Mercier B, et al. Impaired social cognition in mild Alzheimer disease. J Geriatr Psychiatry Neurol 2009; 22(2): 130-40.
[http://dx.doi.org/10.1177/0891988709332939] [PMID: 19321881]
[17]
Klein-Koerkamp Y, Baciu M, Hot P. Preserved and impaired emotional memory in Alzheimer’s disease. Front Psychol 2012; 3: 331.
[http://dx.doi.org/10.3389/fpsyg.2012.00331] [PMID: 23049516]
[18]
Kumfor F, Irish M, Leyton C, et al. Tracking the progression of social cognition in neurodegenerative disorders. J Neurol Neurosurg Psychiatry 2014; 85(10): 1076-83.
[http://dx.doi.org/10.1136/jnnp-2013-307098] [PMID: 24569686]
[19]
Bora E, Walterfang M, Velakoulis D. Theory of mind in behavioural-variant frontotemporal dementia and Alzheimer’s disease: A meta-analysis. J Neurol Neurosurg Psychiatry 2015; 86(7): 714-9.
[http://dx.doi.org/10.1136/jnnp-2014-309445] [PMID: 25595152]
[20]
Moher D, Liberati A, Tetzlaff J, Altman DG. PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. PLoS Med 2009; 6(7) e1000097
[http://dx.doi.org/10.1371/journal.pmed.1000097] [PMID: 19621072]
[21]
El Haj M, Gély-Nargeot MC, Raffard S. Destination memory and cognitive theory of mind in Alzheimer’s disease. J Alzheimers Dis 2015; 48(2): 529-36.
[http://dx.doi.org/10.3233/JAD-150467] [PMID: 26402016]
[22]
Bertoux M, de Souza LC, O’Callaghan C, et al. Social cognition deficits: The key to discriminate behavioral variant frontotemporal dementia from Alzheimer’s disease regardless of amnesia? J Alzheimers Dis 2016; 49(4): 1065-74.
[http://dx.doi.org/10.3233/JAD-150686] [PMID: 26756325]
[23]
Cosentino S, Zahodne LB, Brandt J, et al. Social cognition in Alzheimer’s disease: A separate construct contributing to dependence. Alzheimers Dement 2014; 10(6): 818-26.
[http://dx.doi.org/10.1016/j.jalz.2013.12.021] [PMID: 24656839]
[24]
Fliss R, Le Gall D, Etcharry-Bouyx F, Chauviré V, Desgranges B, Allain P. Theory of Mind and social reserve: Alternative hypothesis of progressive Theory of Mind decay during different stages of Alzheimer’s disease. Soc Neurosci 2016; 11(4): 409-23.
[http://dx.doi.org/10.1080/17470919.2015.1101014] [PMID: 26490734]
[25]
Kéri S. Social influence on associative learning: Double dissociation in high-functioning autism, early-stage behavioural variant frontotemporal dementia and Alzheimer’s disease. Cortex 2014; 54: 200-9.
[http://dx.doi.org/10.1016/j.cortex.2014.02.018] [PMID: 24709075]
[26]
Laisney M, Bon L, Guiziou C, Daluzeau N, Eustache F, Desgranges B. Cognitive and affective Theory of Mind in mild to moderate Alzheimer’s disease. J Neuropsychol 2013; 7(1): 107-20.
[http://dx.doi.org/10.1111/j.1748-6653.2012.02038.x] [PMID: 23088554]
[27]
Le Bouc R, Lenfant P, Delbeuck X, et al. My belief or yours? Differential theory of mind deficits in frontotemporal dementia and Alzheimer’s disease. Brain 2012; 135(Pt 10): 3026-38.
[http://dx.doi.org/10.1093/brain/aws237] [PMID: 23065791]
[28]
Narme P, Mouras H, Roussel M, Devendeville A, Godefroy O. Assessment of socioemotional processes facilitates the distinction between frontotemporal lobar degeneration and Alzheimer’s disease. J Clin Exp Neuropsychol 2013; 35(7): 728-44.
[http://dx.doi.org/10.1080/13803395.2013.823911] [PMID: 23930667]
[29]
Narme P, Roussel M, Mouras H, Krystkowiak P, Godefroy O. Does impaired socioemotional functioning account for behavioral dysexecutive disorders? Evidence from a transnosological study. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 2017; 24(1): 80-93.
[http://dx.doi.org/10.1080/13825585.2016.1171291] [PMID: 27054957]
[30]
Ramanan S, Cruz de Souza L, Moreau N, Sarazin M, Teixeira A, Allen Z, et al. Determinants of theory of mind performance in Alzheimer’s disease: A data-mining study. Cortex 2017; 88: 8-18.
[31]
Shany-Ur T, Poorzand P, Grossman SN, et al. Comprehension of insincere communication in neurodegenerative disease: Lies, sarcasm, and theory of mind. Cortex 2012; 48(10): 1329-41.
[http://dx.doi.org/10.1016/j.cortex.2011.08.003] [PMID: 21978867]
[32]
Dodich A. Combined socio-behavioral evaluation improves the differential diagnosis between the behavioral variant of frontotemporal dementia and Alzheimer’s disease: In search of neuropsychological markers. J Alzheimers Dis 2018; 761-2.
[33]
Reul S, Lohmann H, Wiendl H, Duning T, Johnen A. Can cognitive assessment really discriminate early stages of Alzheimer’s and behavioural variant frontotemporal dementia at initial clinical presentation? Alzheimers Res Ther 2017; 9(1): 61.
[http://dx.doi.org/10.1186/s13195-017-0287-1] [PMID: 28793933]
[34]
Torres B, Santos RL, Sousa MF, et al. Facial expression recognition in Alzheimer’s disease: A longitudinal study. Arq Neuropsiquiatr 2015; 73(5): 383-9.
[http://dx.doi.org/10.1590/0004-282X20150009] [PMID: 26017202]
[35]
Leslie A, Friedman O, German T. Core mechanisms in “theory of mind”. Trends Cogn Sci 2004; 8(12): 528-33.
[36]
Samson D, Apperly IA, Humphreys GW. Error analyses reveal contrasting deficits in “theory of mind”: Neuropsychological evidence from a 3-option false belief task. Neuropsychologia 2007; 45(11): 2561-9.
[http://dx.doi.org/10.1016/j.neuropsychologia.2007.03.013] [PMID: 17451756]
[37]
Arioli M, Crespi C, Canessa N. Social cognition through the lens of cognitive and clinical neuroscience. BioMed Res Int 2018; 20184283427
[http://dx.doi.org/10.1155/2018/4283427] [PMID: 30302338]
[38]
Mahy CE, Moses LJ, Pfeifer JH. How and where: Theory-of-mind in the brain. Dev Cogn Neurosci 2014; 9: 68-81.
[http://dx.doi.org/10.1016/j.dcn.2014.01.002] [PMID: 24552989]
[39]
Zelazo D, Qu L, Müller U. Hot and cool aspects of executive function: Relations in early development Schumann-Hengsteler R, Sodian B Young children’s cognitive development: Interrelationships among executive functioning, working memory, verbal ability, and theory of mind. Mahwah: Erlbaum 2005; pp. 71-93.
[40]
Nelis SM, Clare L, Martyr A, et al. Awareness of social and emotional functioning in people with early-stage dementia and implications for carers. Aging Ment Health 2011; 15(8): 961-9.
[http://dx.doi.org/10.1080/13607863.2011.575350] [PMID: 21722021]
[41]
McLellan T, Johnston L, Dalrymple-Alford J, Porter R. The recognition of facial expressions of emotion in Alzheimer’s disease: A review of findings. Acta Neuropsychiatr 2008; 20(5): 236-50.
[http://dx.doi.org/10.1111/j.1601-5215.2008.00315.x] [PMID: 26952025 ]


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Article Details

VOLUME: 17
ISSUE: 5
Year: 2020
Published on: 19 August, 2020
Page: [487 - 497]
Pages: 11
DOI: 10.2174/1567205017666200626205154
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