Potential Immunotherapy against SARS-CoV-2: Strategy and Status

Author(s): Abid H. Banday*, Shameem A. Shah, Sheikh J. Ajaz

Journal Name: Coronaviruses
The World's First International Journal Dedicated to Coronaviruses

Volume 1 , Issue 1 , 2020

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SARS-CoV-2, the novel coronavirus that was first reported in Wuhan, China in December 2019, has engrossed the world with immense distress. It has shattered the global healthcare system and has inflicted so much pain on humanity. COVID-19, the disease caused by a microscopic enemy, has now spread to almost all the countries in the world affecting millions of people and causing enormous casualties. World Health Organization (WHO) declared COVID-19 a pandemic on March 11, 2019. As of June 15, 2020, almost 7.70 million people have already been infected globally with 428,000 reported casualties. In the United States alone, 2.14 million people have been infected and 117,000 people have succumbed to this pandemic. A multipronged approach has been launched towards combating this pandemic with the main focus on exhaustive screening, developing efficacious therapies, and vaccines for long-term immunity. Several pharmaceutical companies in collaboration with various academic institutions and governmental organizations have started investigating new therapeutics and repurposing approved drugs so as to find fast and affordable treatments against this disease. The present communication aims at highlighting the efforts that are currently underway to treat or prevent SARS-CoV-2 infection through immunotherapy. Emphasis has been laid on discussing the approaches and platforms that are being utilized for the speedy development of therapeutic antibodies and preventive vaccines against SARS-CoV-2. The manuscript also presents a detailed discussion regarding strategy, clinical status, and timeline for the development of safe and enduring immunotherapy against SARS-CoV-2. All the details pertaining to the clinical status of each candidate have been last updated on June 15, 2020.

Keywords: COVID-19, SARS-CoV-2, ACE2 receptors, immunotherapy, monoclonal antibodies, Vaccines.

Andersen KG, Rambaut A, Lipkin WI, Holmes EC, Garry RF, Garry RF. The proximal origin of SARS-CoV-2. Nat Med 2020; 26(4): 450-2.
[http://dx.doi.org/10.1038/s41591-020-0820-9] [PMID: 32284615]
Wang H, Li X, Li T, et al. The genetic sequence, origin, and diagnosis of SARS-CoV-2. Eur J Clin Microbiol Infect Dis 2020; 4: 1-7.
[PMID: 32333222]
Boni MF, Lemey P, Jiang X, et al. Evolutionary origins of the SARS-CoV-2 sarbecovirus lineage responsible for the COVID-19 pandemic. bioRxiv 2020.
Amanat F, Krammer F. SARS-CoV-2 Vaccines: Status Report. Immunity 2020; 52(4): 583-9
[http://dx.doi.org/10.1016/j.immuni.2020.03.007] [PMID: 32259480]
Ou X, Liu Y, Lei X, et al. Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV. Nat Commun 2020; 11(1): 1620
[http://dx.doi.org/10.1038/s41467-020-15562-9] [PMID: 32221306]
Bombardini T, Picano E. Angiotensin-Converting Enzyme 2 as the molecular bridge between epidemiologic and clinical features of COVID-19. Can J Cardiol 2020; 36(5): 784.e1-2
[http://dx.doi.org/10.1016/j.cjca.2020.03.026] [PMID: 32299780]
Xia H, Lazartigues E. Angiotensin-converting enzyme 2 in the brain: properties and future directions. J Neurochem 2008; 107(6): 1482-94.
[http://dx.doi.org/10.1111/j.1471-4159.2008.05723.x] [PMID: 19014390]
Baig AM. Neurological manifestations in COVID-19 caused by SARS-CoV-2. CNS Neurosci Ther 2020; 26(5): 499-501
[http://dx.doi.org/10.1111/cns.13372] [PMID: 32266761]
Baig AM, Khaleeq A, Ali U, Syeda H. Evidence of the COVID-19 virus targeting the cns: tissue distribution, host-virus interaction, and proposed neurotropic mechanisms. ACS Chem Neurosci 2020; 11(7): 995-8
[http://dx.doi.org/10.1021/acschemneuro.0c00122] [PMID: 32167747]
Burkard C, Verheije MH, Wicht O, et al. Coronavirus cell entry occurs through the endo-/lysosomal pathway in a proteolysisdependent manner. PLoS Pathog 2014; 10(11): e1004502
[http://dx.doi.org/10.1371/journal.ppat.1004502] [PMID: 25375324]
Modes of transmission of virus causing COVID-19: implications for IPC precaution recommendations https://www.who.int/news-room/commentaries/detail/modes-of-transmission-of-virus-causing-covid-19-implications-for-ipc-precaution-recommendations
Baud D, Qi X, Nielsen-Saines K, Musso D, Pomar L, Favre G. Real estimates of mortality following COVID-19 infection. Lancet Infect Dis 2020; S1473-3099(20): 30195-X
[http://dx.doi.org/10.1016/S1473-3099(20)30195-X] [PMID: 32171390]
Li Q, Guan X, Wu P, et al. Early Transmission dynamics in wuhan, china, of novel coronavirus-infected pneumonia. N Engl J Med 2020; 382(13): 1199-207
[http://dx.doi.org/10.1056/NEJMoa2001316] [PMID: 31995857]
Naran K, Nundalall T, Chetty S, Barth S. Principles of Immunotherapy: Implications for Treatment Strategies in Cancer and Infectious Diseases. Front Microbiol 2018; 9: 3158-80.
[http://dx.doi.org/10.3389/fmicb.2018.03158] [PMID: 30622524]
Seib KL, Dougan G, Rappuoli R. The key role of genomics in modern vaccine and drug design for emerging infectious diseases. PLoS Genet 2009; 5(10): e1000612
[http://dx.doi.org/10.1371/journal.pgen.1000612] [PMID: 19855822]
Du L, He Y, Zhou Y, Liu S, Zheng BJ, Jiang S. The spike protein of SARS-CoV--a target for vaccine and therapeutic development. Nat Rev Microbiol 2009; 7(3): 226-36
[http://dx.doi.org/10.1038/nrmicro2090] [PMID: 19198616]
Jiang S, He Y, Liu S. SARS vaccine development Emerg Infect Dis 2005; 11(7): 1016-20..
[http://dx.doi.org/10.3201/1107.050219] [PMID: 16022774]
Gabriella, di.M.; Cristina, S.; Concetta, R.; Francesco, R.; Annalisa, C. SARS-CoV-2 infection: Response of human immune system and possible implications for the rapid test and treatment. Int Immunopharmacol 2020; 84: 106519-21
In the race to develop a coronavirus treatment, regeneron thinks it has the inside track https://www.statnews.com/2020/02/05/in-the-race-to-develop-a-coronavirus-treatment-regeneron-thinks-it-has-the-inside-track/
Kevzara (Sarilumab). A Novel IL-6 Receptor Antagonist for Rheumatoid Arthritis http://www.ahdbonline.com/supplements/2438-kevzara-sarilumab-a-novel-il-6-receptor-antagonist-for-rheumatoid-arthritis
Lamb YN, Deeks ED. Sarilumab: A Review in Moderate to Severe Rheumatoid Arthritis Drugs 2018; 78(9): 929-40.
[http://dx.doi.org/10.1007/s40265-018-0929-z] [PMID: 29931592]
FDA Approves Sarilumab for Adults With Rheumatoid Arthritis https://www.medscape.com/viewarticle/880473
EU approval for Regeneron and Sanofi’s rheumatoid arthritis drug https://www.europeanpharmaceuticalreview.com/news/62816/eu-approval-kevzara/
Sanofi, Regeneron launch trials of arthritis drug Kevzara for COVID-19 http://www.pmlive.com/pharmanews/sanofi,regeneron
Sanofi and Regeneron begin global Kevzara (sarilumab) clinical trial program in patients with severe COVID-19 http://www.news.sanofi.us/2020-03-16-Sanofi-and-Regeneron-begin-global-Kevzara-R-sarilumab-clinical-trial-program-in-patients-with-severe-COVID-19
Wrapp D, Wang N, Corbett KS, et al. Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Science 2020; 367(6483): 1260-3.
[http://dx.doi.org/10.1126/science.abb2507] [PMID: 32075877]
Lan J, Ge J, Yu J, et al. Crystal structure of the 2019-nCoV spike receptor-binding domain bound with the ACE2 receptor. bioRxiv 2019. https://www.biorxiv.org/content/10.1101/2020.02.19.956235v1
Rota PA, Oberste MS, Monroe SS, et al. Characterization of a novel coronavirus associated with severe acute respiratory syndrome Science 2003; 300(5624): 1394-9..
[http://dx.doi.org/10.1126/science.1085952] [PMID: 12730500]
Thiel V, Ivanov KA, Putics Á, et al. Mechanisms and enzymes involved in SARS coronavirus genome expression. J Gen Virol 2003; 84(Pt 9): 2305-15.
[http://dx.doi.org/10.1099/vir.0.19424-0] [PMID: 12917450]
AbCellera and Lilly to Co-develop Antibody Therapies for the Treatment of COVID-19. https://investor.lilly.com/news-releases/news-release-details/abcellera-and-lilly-co-develop-antibody-therapies-treatment2020
Pharma chiefs expect coronavirus vaccine in 12-18 months https://www.dawn.com/news/1542367
Moderna, NIAID Partner on Planned Trial of Coronavirus mRNA Vaccine https://www.genengnews.com/news/moderna-niaid-partner-on-planned-trial-of-coronavirus-mrna-vaccine/
Moderna Announces First Participant Dosed in NIH-led Phase 1 Study of mRNA Vaccine (mRNA-1273) Against Novel Coronavirus. https://www.businesswire.com/news/home/20200316005666/en/Moderna-Announces-Participant-Dosed-NIH-led-Phase-1
A second potential COVID-19 vaccine, backed by Bill and Melinda Gates, is entering human testing https://techcrunch.com/2020/04/06/a-second-potential-covid-19-vaccine-backed-by-bill-and-melinda-gates-is-entering-human-testing/
Pfizer and BioNTech announce further details on collaboration to accelerate global covid-19 vaccine https://www.pfizer.com/news/press-release/press-release-detail/pfizer-and-biontech-announce-further-details-collaboration
Arcturus Therapeutics Announces Clinical Trial Timeline for its COVID-19 Vaccine https://www.biospace.com/article/releases/arcturus-therapeutics-announces-clinical-trial-timeline-for-its-covid-19-vaccine/
About CureVac’s activities regarding an mRNA based vaccine against COVID-19 https://www.curevac.com/covid-19#
CureVac and CEPI extend their Cooperation to Develop a Vaccine against Coronavirus nCoV-2019 https://centerforvaccineethicsandpolicy.net/2020/02/02/announcements-142/
CureVac focuses on the development of mRNA-based coronavirus vaccine to protect people worldwide https://www.curevac.com/news/curevac-focuses-on-the-development-of-mrna-based-coronavirus-vaccine-to-protect-people-worldwide
China's CanSino pushes coronavirus vaccine into clinical testing as Moderna kicks off trial https://www.businesswire.com/news/home/20200316005666/en/Moderna-Announces-Participant-Dosed-NIH-led-Phase-1
A Phase II Clinical Trial to Evaluate the Recombinant Vaccine for COVID-19 (Adenovirus Vector) (CTII-nCoV) https://clinicaltrials.gov/ct2/show/NCT04341389
Oxford COVID-19 vaccine to begin phase II/III human trials http://www.ox.ac.uk/news/2020-05-22-oxford-covid-19-vaccine-begin-phase-iiiii-human-trials
Johnson Johnson Announces a Lead Vaccine Candidate for COVID-19; Landmark New Partnership with US Department of Health Human Services; and Commitment to Supply One Billion Vaccines Worldwide for Emergency Pandemic Use https://www.jnj.com/johnson-johnson-announces-a-lead-vaccine-candidate-for-covid-19-landmark-new-partnership-with-u-s-department-of-health-human-services-and-commitment-to-supply-one-billion-vaccines-worldwide-for-emergency-pandemic-use
Johnson Johnson Announces Acceleration of its COVID-19 Vaccine Candidate; Phase 1/2a Clinical Trial to Begin in Second Half of July https://www.jnj.com/johnson-johnson-announces-acceleration-of-its-covid-19-vaccine-candidate-phase-1-2a-clinical-trial-to-begin-in-second-half-of-july
Johnson Johnson will have 600-800 million coronavirus vaccines by 2021 2021. https://nypost.com/2020/04/15/johnson-johnson-eyes-600-million-coronavirus-vaccines-by-early-2021/
Sanofi and GSK to join forces in unprecedented vaccine collaboration to fight COVID-19 https://www.sanofi.com/en/media-room/press-releases/2020/2020-04-14-13-00-00
Sinovac says early data show its Covid-19 vaccine generated immune responses https://www.statnews.com/2020/06/14/sinovac-early-data-covid19-vaccine-generated-immune-responses/
Brennan FR, Dougan G. Non-clinical safety evaluation of novel vaccines and adjuvants: new products, new strategies. Vaccine 2005; 23(24): 3210-22.
[http://dx.doi.org/10.1016/j.vaccine.2004.11.072] [PMID: 15837222]

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Year: 2020
Page: [23 - 31]
Pages: 9
DOI: 10.2174/2666796701999200625212040

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