Single-cell Sequencing in the Field of Stem Cells

Author(s): Tian Chen, Jiawei Li, Yichen Jia, Jiyan Wang, Ruirui Sang, Yi Zhang*, Ruiming Rong*

Journal Name: Current Genomics

Volume 21 , Issue 8 , 2020

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Graphical Abstract:


Variation and heterogeneity between cells are the basic characteristics of stem cells. Traditional sequencing analysis methods often cover up this difference. Single-cell sequencing technology refers to the technology of high-throughput sequencing analysis of genomes at the single-cell level. It can effectively analyze cell heterogeneity and identify a small number of cell populations. With the continuous progress of cell sorting, nucleic acid extraction and other technologies, single-cell sequencing technology has also made great progress. Encouraging new discoveries have been made in stem cell research, including pluripotent stem cells, tissue-specific stem cells and cancer stem cells. In this review, we discuss the latest progress and future prospects of single-cell sequencing technology in the field of stem cells.

Keywords: Single-cell sequencing, pluripotent stem cell, tissue-specific stem cell, cancer stem cell, RNA sequencing, heterogeneity.

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Article Details

Year: 2020
Published on: 21 December, 2020
Page: [576 - 584]
Pages: 9
DOI: 10.2174/1389202921999200624154445
Price: $65

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PDF: 63