The Preliminary Identification of Potential Vaccine Targets for SARSCoV2 and Computer-aided Synthesis ("Small Interfering RNA Design")

Author(s): Mohammed Mouhcine, Youness Kadil*, Houda Filali

Journal Name: Current Enzyme Inhibition

Volume 16 , Issue 3 , 2020


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Abstract:

Introduction: Coronaviruses constitute the subfamily Orthocoronavirinae, in the Coronaviridae family. Those viruses are a positive-sense and very long single-stranded RNA viruses. Infection- related to SARS CoV2 was named as a pandemic disease by the World Health Organization on Mars 4, 2020.

Aim and Objective: The objective of this work is the identification of potential vaccine targets of SARS CoV2. We aim to provide the potential therapeutic target that can inhibit the spread of virus and identify miRNAs, and reminding proposals to improving the effectiveness of these vaccines.

Methods: Several clinical trials have been stated to design the management process against this pathology and the most proposed drugs have been commercialized for other viral pathologies. Thus, no specific therapeutic protocol has been established.

Results: Our result showed that the potential molecules may specific region in the viral ARN and exert an inhibitor activity against the viral transcription.

Conclusion: We conclude throughout our results that several potential therapeutic targets can act at different stages of the viral life cycle by identifying siRNA interfering with molecules that may inhibit viral replication.

Keywords: ARN polymerase, COVID19, SARS CoV2, small interfering RNA, vaccine, viral particles.

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Article Details

VOLUME: 16
ISSUE: 3
Year: 2020
Published on: 04 November, 2020
Page: [238 - 242]
Pages: 5
DOI: 10.2174/1573408016999200624153546
Price: $65

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