Chemical Screening and Biological Activities of Extracts from Cistus munbyi Pomel

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Author(s): Fethi Benbelaïd*, Abdelmounaїm Khadir, Yacine Benziane, Asma Bennaissa, Mourad Bendahou

Journal Name: Current Traditional Medicine

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Background: Cistus munbyi Pomel is a well-known medicinal plant in Western Algeria for its several applications in medicine and food. This endemic species to North Africa is poorly studied among the genus of Cistus, which gives the opportunity to carry out original pharmacological studies to value this medicinal plant.

Objective: To investigate the antioxidant and the antimicrobial activities of Cistus munbyi, an endemic medicinal plant to Algeria.

Methods: The antioxidant properties of C. munbyi crudes extracts were evaluated using the DPPH radical-scavenging activity tests. While their antimicrobial activity was studied by the agar diffusion method and MICs determination against eighteen bacterial and fungal strains, some of which were clinical.

Results: The obtained results showed that aqueous and ethanol extracts possess a strong scavenging activity against DPPH radicals with EC50 values estimated at 1.12 and 8.31 µg/mL, respectively. On the other hand, extracts from C. munbyi revealed homogeneous and good antimicrobial activity, in which the inhibition zone diameters observed were ranging from 08 to 19 mm, and the MICs values were included between 0.312 and 5.000 mg/mL. Aqueous extract was the less active except against Proteus mirabilis and Staphylococcus aureus.

Conclusion: The findings of this study indicate that C. munbyi possess a strong antioxidant activity and an interesting antimicrobial potential, which allow justifying its uses by the local population in several applications. Therefore, C. munbyi could be as a good source of natural antioxidants and antimicrobial agents.

Keywords: Antimicrobial activity, Antioxidant activity, Cistus munbyi, Crude extracts, Endemic.

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(E-pub Ahead of Print)
DOI: 10.2174/2215083806999200622142149
Price: $95

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