Epigenetic Studies in Psychotherapy: A Systematic Review

Author(s): Rafael Penadés*, Bárbara Arias, Mar Fatjó-Vilas, Laura González-Vallespí, Clemente García-Rizo, Rosa Catalán, Miquel Bernardo

Journal Name: Current Psychiatry Research and Reviews
Formerly Current Psychiatry Reviews

Volume 16 , Issue 2 , 2020

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Graphical Abstract:


Background: Epigenetic modifications appear to be dynamic and they might be affected by environmental factors. The possibility of influencing these processes through psychotherapy has been suggested.

Objective: To analyse the impact of psychotherapy on epigenetics when applied to mental disorders. The main hypothesis is that psychological treatments will produce epigenetic modifications related to the improvement of treated symptoms.

Methods: A computerised and systematic search was completed throughout the time period from 1990 to 2019 on the PubMed, ScienceDirect and Scopus databases.

Results: In total, 11 studies were selected. The studies were evaluated for the theoretical framework, genes involved, type of psychotherapy and clinical challenges and perspectives. All studies showed detectable changes at the epigenetic level, like DNA methylation changes, associated with symptom improvement after psychotherapy.

Conclusion: Methylation profiles could be moderating treatment effects of psychotherapy. Beyond the detected epigenetic changes after psychotherapy, the epigenetic status before the implementation could act as an effective predictor of response.

Keywords: Epigenetics, DNA methylation, psychotherapy, psychopathology, gene-environment, mental disorders.

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Article Details

Year: 2020
Published on: 07 December, 2020
Page: [86 - 92]
Pages: 7
DOI: 10.2174/2666082216999200622140922
Price: $65

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