Thiamine hydrochloride is reported to be a highly competent promoter for the synthesis of
bis(indolyl)methanes under solvent free conditions using microwave irradiation and ultrasonicator heating in
aqueous media. Vitamin B1 is an economical, non-toxic, nonflammable and water soluble green organocatalyst.
Moreover, the simple approach, easily operational, short reaction time, high yield and using a little quantity of
thiamine hydrochloride makes this method an alternative approach. Present protocol is a simple and eco-friendly
approach for the synthesis of bis(indolyl)methanes under microwave and ultrasonicator conditions.
Keywords: Microwave condition, ultrasonicator condition, green catalyst, vitamin B1, one-pot synthesis, solvent free condition.
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