Title:Efficient and Green Synthesis of Bis(indolyl)Methanes using Thiamine Hydrochloride as an Organocatalyst: A Parallel Scrutiny of Microwave Irradiation versus Ultrasonicator Heating in Water
VOLUME: 17 ISSUE: 8
Author(s):Nitin M. Thorat*, Kiran D. Dhawale, Sandeep B. Kasar, Manali S. Thopate, Limbraj R. Patil and Shankar R. Thopate
Affiliation:Department of Chemistry, Maharaja Jivajirao Shinde Arts, Science, Commerce College, Shrigonda Maharashtra 413701, Department of Chemistry, Maharaja Jivajirao Shinde Arts, Science, Commerce College, Shrigonda Maharashtra 413701, Department of Chemistry, Prof. John Barnabas Post Graduate School for Biological Studies, Ahmednagar College, Ahmednagar, Department of Chemistry, Shri Sadguru Gangageer Maharaj Science, Guatum Arts & Sanjivani Commerce College, Kopargoan, Dist. Ahmednagar – 423 601, Maharashtra, Department of Chemistry, Maharaja Jivajirao Shinde Arts, Science, Commerce College, Shrigonda Maharashtra 413701, Department of Chemistry, Prof. John Barnabas Post Graduate School for Biological Studies, Ahmednagar College, Ahmednagar
Keywords:Microwave condition, ultrasonicator condition, green catalyst, vitamin B1, one-pot synthesis, solvent free condition.
Abstract:Thiamine hydrochloride is reported to be a highly competent promoter for the synthesis of
bis(indolyl)methanes under solvent free conditions using microwave irradiation and ultrasonicator heating in
aqueous media. Vitamin B1 is an economical, non-toxic, nonflammable and water soluble green organocatalyst.
Moreover, the simple approach, easily operational, short reaction time, high yield and using a little quantity of
thiamine hydrochloride makes this method an alternative approach. Present protocol is a simple and eco-friendly
approach for the synthesis of bis(indolyl)methanes under microwave and ultrasonicator conditions.
