Efficient and Green Synthesis of Bis(indolyl)Methanes using Thiamine Hydrochloride as an Organocatalyst: A Parallel Scrutiny of Microwave Irradiation versus Ultrasonicator Heating in Water

Author(s): Nitin M. Thorat*, Kiran D. Dhawale, Sandeep B. Kasar, Manali S. Thopate, Limbraj R. Patil, Shankar R. Thopate

Journal Name: Current Organic Synthesis

Volume 17 , Issue 8 , 2020

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Graphical Abstract:


Thiamine hydrochloride is reported to be a highly competent promoter for the synthesis of bis(indolyl)methanes under solvent free conditions using microwave irradiation and ultrasonicator heating in aqueous media. Vitamin B1 is an economical, non-toxic, nonflammable and water soluble green organocatalyst. Moreover, the simple approach, easily operational, short reaction time, high yield and using a little quantity of thiamine hydrochloride makes this method an alternative approach. Present protocol is a simple and eco-friendly approach for the synthesis of bis(indolyl)methanes under microwave and ultrasonicator conditions.

Keywords: Microwave condition, ultrasonicator condition, green catalyst, vitamin B1, one-pot synthesis, solvent free condition.

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Article Details

Year: 2020
Published on: 17 November, 2020
Page: [679 - 684]
Pages: 6
DOI: 10.2174/1570179417666200620215101
Price: $65

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