Preclinical Evidence for the Pharmacological Actions of Glycyrrhizic Acid: A Comprehensive Review

Author(s): Muneeb U. Rehman*, Adil Farooq, Rayeesa Ali, Sana Bashir, Nazirah Bashir, Samia Majeed, Syed Taifa, Sheikh Bilal Ahmad, Azher Arafah, Aga Syed Sameer*, Rehan Khan, Wajhul Qamar, Saiema Rasool, Anas Ahmad

Journal Name: Current Drug Metabolism

Volume 21 , Issue 6 , 2020


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Graphical Abstract:


Abstract:

Glycyrrhiza glabra L. (Family: Fabaceae) is one of the important traditional medicinal plant used extensively in folk medicine. It is known for its ethnopharmacological value in curing a wide variety of ailments. Glycyrrhizin, an active compound of G. glabra, possesses anti-inflammatory activity due to which it is mostly used in traditional herbal medicine for the treatment and management of chronic diseases. The present review is focused extensively on the pharmacology, pharmacokinetics, toxicology, and potential effects of Glycyrrhizic Acid (GA). A thorough literature survey was conducted to identify various studies that reported on the GA on PubMed, Science Direct and Google Scholar.

Keywords: Glycyrrhiza glabra, liquorice, glycyrrhizin, medicinal plant, fabaceae, anti-inflammatory.

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VOLUME: 21
ISSUE: 6
Year: 2020
Published on: 24 September, 2020
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DOI: 10.2174/1389200221666200620204914
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