A Review On Expedient Assets Of Polymers Employed In Novel Topical Formulation For Successful Treatment Of Arthritis

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Author(s): Suchitra Nishal, Vikas Jhawat*, Parmita Phaugat

Journal Name: Current Applied Polymer Science

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Abstract:

Background: An autoimmune ailment rheumatoid arthritis (RA) where body’s defense system is violated by damaging its own joints. In RA treatment strategies, attempts had been made for oral, topical and parenteral formulations with different drugs, but none of the formulation could be regarded as perfect dosage form. In the current review, meticulous discussion has been done for the suitability of novel topical formulation in treatment of RA. Moreover emphasize has been made on activities of biodegradable polymers such as hyaluronic acid, lecithin, pluronic acid, chitosan, human serum albumin (HSA) and poly lactide glycolic acid (PLGA) as well as their role in the management of RA.

Objective: To apprehend the role of polymeric materials in developing ideal topical drug delivery system which can bestow targeted delivery, enhanced penetration of drug, improved stability of the formulation and improved PKPD profile of the drugs. These polymers possess twinfold functions, primarily by increasing the skin penetration and secondarily by improving the joint mobility and cartilage regeneration. Furthermore, biocompatibility and biodegradbility are the features which amplifies the use of aforementioned polymers.

Results: Significant role of all the polymers in improving the conditions of bones and joints suffering from rheumatoid arthritis, has been demonstrated by various studies.

Keywords: Polymer, Topical, Biocompatible, Biodegradable, Cartilage regeneration, Rheumatoid Arthritis

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/2452271604999200620184631
Price: $95

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