Monocyclic β -Lactam: A Review on Synthesis and Potential Biological Activities of a Multitarget Core

Author(s): Taíse H.O. Leite, Mauricio F. Saraiva*, Alessandra C. Pinheiro, Marcus Vinícius N. de Souza

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 20 , Issue 16 , 2020

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Graphical Abstract:


A monocyclic ring in their structure characterizes monobactams, a subclass of β-lactam antibiotics. Many of these compounds have a bactericidal mechanism of action and acts as penicillin and cephalosporins, interfering with bacterial cell wall biosynthesis. The synthesis of novel β-lactams is an emerging area of organic synthesis research due to the problem of increasing bacterial resistance to existing β -lactam antibiotics, and, in this way, new compounds have been presented with several structural modifications, aiming to improve biological activities. Among the biological activities studied, the most outstanding are antibacterial, antitubercular, anticholesterolemic, anticancer, antiinflammatory, antiviral, and anti-enzymatic, among others. This review explores the vast number of works related to monocyclic β-lactams, compounds of great importance in scientific research.

Keywords: Antibiotic, monocyclic β-lactam, pharmacological profile, four membered heterocyclic ring, anticancer, antiinflammatory.

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Article Details

Year: 2020
Published on: 10 November, 2020
Page: [1653 - 1682]
Pages: 30
DOI: 10.2174/1389557520666200619114820
Price: $65

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