Lethality due to dengue infection is a global threat. Nearly 400 million people are affected
every year, which approximately costs 500 million dollars for surveillance and vector control itself.
Many investigations on the structure-function relationship of proteins expressed by the dengue virus are
being made for more than a decade and had come up with many reports on small molecule drug discovery.
In this review, we present a detailed note on viral proteins and their functions as well as the inhibitors
discovered/designed so far using experimental and computational methods. Further, the phytoconstituents
from medicinal plants, specifically the extract of the papaya leaves, neem and bael, which combat
dengue infection via dengue protease, helicase, methyl transferase and polymerase are summarized.
Keywords: Dengue virus, Structure-based drug design, Fragment-based drug designing, Pharmacophore, QSAR, Docking.
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