Background: Stroke is one of the causes of death and disability globally. Brain attack is
because of the acute presentation of stroke, which highlights the requirement for decisive action to
Objective: The mechanism and in-vivo experimental models of stroke with various neuroprotective
agents are highlighted in this review.
Method: The damaging mechanisms may proceed by rapid, nonspecific cell lysis (necrosis) or by the
active form of cell death (apoptosis or necroptosis), depending upon the duration and severity and of
the ischemic insult.
Results: Identification of injury mediators and pathways in a variety of experimental animal models of
global cerebral ischemia has directed to explore the target-specific cytoprotective strategies, which are
critical to clinical brain injury outcomes.
Conclusion: The injury mechanism, available encouraging medicaments thereof, and outcomes of
natural and modern medicines for ischemia have been summarized. In spite of available therapeutic
agents (thrombolytics, calcium channel blockers, NMDA receptor antagonists and antioxidants), there
is a need for an ideal drug for strokes.