Recent Advances in Transition Metal Free Synthetic Protocols for Quinoline Derivatives

Author(s): Rukhsana Tabassum*, Muhammad Ashfaq*, Hiroyuki Oku

Journal Name: Current Organic Chemistry

Volume 24 , Issue 16 , 2020

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Graphical Abstract:


The quinoline moiety is a privileged scaffold among heterocyclic compounds that is an important construction motif in the fields of pharmaceutical chemistry. Quinoline molecule possesses a variety of therapeutic activities like antiviral, antimalarial, antibacterial, antitumor, anticancer, antioxidant antihypertensive, antifungal, anthelmintic, cardiotonic, anticonvulsant and anti-inflammatory. This review provides an insight into recent development in transition metal free novel and modified conventional synthetic routes to yield a wide variety of substituted quinolines.

Keywords: Quinoline, quinoline derivatives, transition metal free, heterocyclic compounds, synthetic protocols, therapeutic activities.

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Year: 2020
Published on: 16 June, 2020
Page: [1815 - 1852]
Pages: 38
DOI: 10.2174/1385272824999200616122557
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