Background: For the past several decades, the presence of tuberculosis (TB) is being
remarked as the most common infectious disease leading to mortality.
Objective: Hydrazone containing azometine group (-NHN=CH-) compounds have been reported
for a broad range of bioactivities such as antiplatelet, analgesic, anti-inflammatory, anticonvulsant,
antidepressant, antimalarial, vasodilator, antiviral, and antimicrobial, etc.
Methods: For the synthesis of compounds (4a-4d) and (6a-6e), aromatic amines were treated with
methyl terephthalaldehydate in methanol, giving Schiff’s bases, followed by reductive amination
and further treatment with hydrazine hydrate gave acid hydrazides (4a-4d). These acid hydrazides
were then treated with different aromatic aldehydes to yield hydrazones (6a-6d). All the synthesized
compounds were subjected to FT-IR, NMR, and UV spectroscopic characterization.
Results: Compounds (4a-4d) and (6a-6e) were found to have highly potent activity against Mycobacteria
tuberculosis (Vaccine strain, H37 RV strains): ATCC No- 27294 (MIC:1.6-6.25 μg/mL)
than standard anti-TB drugs. The compounds exhibited good radical scavenging potentials(0-
69.2%), as checked from DPPH protocol. All compounds also demonstrated good in-silico ADMET
Conclusion: The current study revealed promising in vitro anti-tuberculosis and anti-oxidant profiles
of hydrazide-hydrazone analogues.