MicroRNAs (miRNAs) are short, non-coding RNA molecules that regulate gene expression by
translational repression or deregulation of messenger RNAs. Accumulating evidence suggests that miRNAs
play various roles in the development and progression of lung cancers. Although their precise roles in targeted
cancer therapy are currently unclear, miRNAs have been shown to affect the sensitivity of tumors to anticancer
drugs. A large number of recent studies have demonstrated that some anticancer drugs exerted antitumor activities
by affecting the expression of miRNAs and their targeted genes. These studies have elucidated the specific
biological mechanism of drugs in tumor suppression, which provides a new idea or basis for their clinical application.
In this review, we summarized the therapeutic mechanisms of drugs in lung cancer therapy through their
effects on miRNAs and their targeted genes, which highlights the roles of miRNAs as targets in lung cancer
Keywords: microRNAs, anticancer drugs, gene regulation, lung cancer, biological targets, cancer therapy.
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