Background: Buccal delivery is an alluring course of organization for fundamental medication conveyance
and it leads direct access to the systemic flow through the interior jugular vein sidesteps drugs from the
hepatic first-pass digestion gives high bioavailability.
Objective: This article aims at buccal medication conveyance by discussing the structure and condition of the oral
mucosa and the novel strategies utilized in evaluating buccal medication ingestion.
Methods: This review highlights the various pharmaceutical approaches for buccal delivery such as buccal tablets,
buccal lozenges, buccal micro/nanoparticle, wafer and semisolid dosage forms like chewing gums, buccal
patch, buccal gel or ointment and some buccal liquid dosage forms like buccal solutions and buccal sprays and
recent patents filed or granted for these approaches.
Results: Recently, some patents are also reported where a combination of various approaches is being employed
to achieve very effective mucosal delivery. The various patent search sites were used to collect and analyze the
information on buccal drug delivery systems.
Conclusion: The present study provides valuable information, advantages, limitations and future outlook of various
buccal drug delivery systems.