Stroke is the second leading cause of death and a major cause of disability worldwide. Both modifiable
and non-modifiable risk factors can affect the occurrence of ischemic stroke at varying degrees. Among them,
atherosclerosis has been well-recognized as one of the main culprits for the rising incidence of stroke-related
mortality. Hence, the current review aimed to summarize the prominent role of lipid metabolism genes such as
PCSK9, ApoB, ApoA5, ApoC3, ApoE, and ABCA1 in mediating ischemic stroke occurrence.
Keywords: Lipids, gene, stroke, metabolism, PCSK9, ApoB, ApoA5, ApoC3, ApoE, ABCA1.
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