Background: Many bioactive molecules such as lycopene, resveratrol, lignan, tannins, indoles fatty acids, etc.
found in small amounts in plants, animals, and microorganisms have been extensively investigated for their diverse preventive, therapeutic, immune-modulating and toxicological effects. Currently, the growing interest of the consumers is shifted
towards a novel bioinspired strategy of cocktailing two or more bioactives at a lower concentration to reduce both side and
cost effects, and to enhance positive effects for the development of novel compounds by the food, pharmaceutical, and
Methods: Even though there are several regularly updated and published reports showing the importance of beneficial effects of bioactives individually, no systematic reviews are outlining how the bioactives have combinatorially acted together
to provide such health benefits and disease preventive effects. Hence, various electronic scientific databases such as Pub
Med, Science Direct, Google scholar, Sci-Finder were searched to collect the data of the present review.
Results: One hundred and sixty-two research and review papers collected from peer-reviewed journals are cited in the present review covering the broad spectrum of many bioactives and their importance in the field of food, feed and drug industries.
Conclusion: The present systematic review discusses and highlights our current knowledge on the concept of synergistic
and combinatorial effects of various bioactives from the plant, animal, microorganism sources and synthetic drugs in disease
prevention and health promotion. These findings may pave a way for the discovery of new bioactive products and process
development, which could add to economic importance.