Rediscovering Tocophersolan: A Renaissance for Nano-Based Drug Delivery and Nanotheranostic Applications

(E-pub Ahead of Print)

Author(s): Dickson Pius Wande, Qin Cui, Shijie Chen, Cheng Xu, Hui Xiong, Jing Yao*

Journal Name: Current Drug Targets

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Abstract:

As a unique and pleiotropic polymer, d-alpha-tocopheryl polyethylene glycol succinate (Tocophersolan) is a polymeric synthetic version of vitamin E. Tocophersolan has attracted enormous attention as a versatile excipient in different biomedical applications including drug delivery systems and nutraceuticals. The multiple inherent properties of Tocophersolan make it play flexible roles in drug delivery system design, including excipients with outstanding biocompatibility, solubilizer with the ability of promoting drug dissolution, drug permeation enhancer, P-glycoprotein inhibitor and anticancer compound. For these reasons, Tocophersolan has been widely used for improving the bioavailability of numerous pharmaceutical active ingredients. Tocophersolan has been approved by stringent regulatory authorities (such as US FDA, EMA, and PMDA) as a safe pharmaceutical excipient. In this review, we systematically curated current advances in nano-based delivery systems consisting of Tocophersolan with possibilities for futuristic applications in drug delivery, gene therapy, and nanotheranostic.

Keywords: Tocophersolan, bioavailability, bio-enhancer, drug delivery, nanoparticles, nanotheranostic

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/1389450121666200611140425
Price: $95

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