Introduction: According to Rome IV, functional dyspepsia is diagnosed with the presence
of dyspepsia in the absence of organic or metabolic causes. FD caused by several factors,
such as impaired gastric accommodation and hypersensitivity to gastric distention. Several studies
have reported the effectiveness of herbal medicine on FD. This article, thus, reviews Persian herbal
medicine in FD.
Methods: Electronic databases, including Pubmed, Scopus, Cochrane, Embase, Web of science
and Ovid, were searched so as to find clinical articles related to dyspepsia and herbal medicine by
July 2019. Our search strategies were traditional medicine, complementary and alternative medicine,
herb, plant, and dyspepsia. We excluded all articles except Persian clinical trials.
Results: We found 34 clinical trials with 15 herbs and 4 compound herbal remedies like Asparagus
racemosus, Brassica oleracea, Cynara scolymus, Ocimum basilicum, Mentha longifolia, Mentha
pulegium, Mentha piperata, Pimpinella anisum, Nigella sativa, Mastic gum, Curcuma longa,
Pistatio Atlantica, Glycyrrhiza glabra, Solanum tuberosum and Zingiber officinale and compound
remedies of Rosa damascene & Crocus sativus, Trachyspermum copticom & Apium graveolence,
Carum carvi & Mentha pipperata, Gingiber officinalis & Cynara scolymus are effective in functional
Conclusion: Many people use herbal and traditional remedies for the treatment of disorders such
as gastrointestinal disorders, especially in Asian countries. Several studies reported the efficacy of
herbal medicine in functional dyspepsia. Although their mechanisms are not fully understood, it
seems they can modulate GI motility and improve symptoms of FD.