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Current Organic Synthesis

Editor-in-Chief

ISSN (Print): 1570-1794
ISSN (Online): 1875-6271

Letter Article

Short Protecting Group-free Syntheses of CDE Synthon of Racemic Camptothecin

Author(s): Pingxuan Shao, Wei Lu and Lei Wang*

Volume 17, Issue 7, 2020

Page: [588 - 591] Pages: 4

DOI: 10.2174/1570179417666200611125740

Price: $65

Abstract

A practical and concise total synthesis of tricyclic ketone 7 (CDE ring), a valuable intermediate for the synthesis of racemic camptothecin and analogs, was described (8 chemical steps and 29% overall yield). The synthesis starts with two inexpensive, readily available materials and is operationally simple to perform. It is worth mentioning that the reported protecting group-free synthesis, with advantages of a short route, would be helpful for the future development of industry-scale syntheses of camptothecin-family alkaloids.

Keywords: Natural product, alkaloid, camptothecin, CDE ring, total syntheses, protecting group-free.

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