Stimulator of interferon genes is an important innate immune signaling molecule in the body and is
involved in the innate immune signal transduction pathway induced by pathogen-associated molecular patterns or
damage-associated molecular patterns. Stimulator of interferon genes promotes the production of type I interferon
and thus plays an important role in the innate immune response to infection. In addition, according to a recent
study, the stimulator of interferon genes pathway also contributes to anti-inflammatory and anti-tumor reactions.
In this paper, current researches on the Stimulator of interferon genes signaling pathway and its relationship with
tumor immunity are reviewed. Meanwhile, a series of critical problems to be addressed in subsequent studies are
discussed as well.
Keywords: STING, innate immune response, type I interferon, cGAMP, cGAS, anti-tumor immunity.
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