Stimulator of Interferon Genes Signaling Pathway and its Role in Anti-tumor Immune Therapy

Author(s): Yuanjin Gong, Chang Chang, Xi Liu, Yan He*, Yiqi Wu*, Song Wang, Chongyou Zhang

Journal Name: Current Pharmaceutical Design

Volume 26 , Issue 26 , 2020


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Abstract:

Stimulator of interferon genes is an important innate immune signaling molecule in the body and is involved in the innate immune signal transduction pathway induced by pathogen-associated molecular patterns or damage-associated molecular patterns. Stimulator of interferon genes promotes the production of type I interferon and thus plays an important role in the innate immune response to infection. In addition, according to a recent study, the stimulator of interferon genes pathway also contributes to anti-inflammatory and anti-tumor reactions. In this paper, current researches on the Stimulator of interferon genes signaling pathway and its relationship with tumor immunity are reviewed. Meanwhile, a series of critical problems to be addressed in subsequent studies are discussed as well.

Keywords: STING, innate immune response, type I interferon, cGAMP, cGAS, anti-tumor immunity.

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VOLUME: 26
ISSUE: 26
Year: 2020
Published on: 11 August, 2020
Page: [3085 - 3095]
Pages: 11
DOI: 10.2174/1381612826666200610183048
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