Synergistic Antioxidant and Antibacterial Activity of Curcumin-C3 Encapsulated Chitosan Nanoparticles

Author(s): Desu N.K. Reddy*, Fu-Yung Huang*, Shao-Pin Wang, Ramya Kumar

Journal Name: Current Pharmaceutical Design

Volume 26 , Issue 39 , 2020

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Background: Recent studies have focused on the nanoformulations of curcumin to enhance its solubility and bioavailability. The medicinal properties of curcumin-C3 complex, which is a combination of three curcuminoids (curcumin, demethoxycurcumin and bisdemethoxycurcumin) is less explored.

Objective: The aim of this study was to prepare curcumin-C3 encapsulated in chitosan nanoparticles, characterize and evaluate their antioxidant and antibacterial potential.

Methods: Ionic gelation method was used to prepare curcumin-C3 nanoparticles and was characterized by Fourier transform infrared spectroscopy, X-ray diffraction, transmission electron microscopy and nanoparticle tracking analysis. In vitro assays were performed to assess drug release, antioxidant and antibacterial activities.

Results: Curcumin-C3-chitosan nanoparticle showed an increased entrapment efficiency of >90%, drug release and improved antioxidant potential. Moreover, curcumin-C3-chitosan nanoparticle showed stronger inhibition of Escherichia coli and Staphylococcus aureus.

Conclusion: Chitosan is a suitable carrier for curcumin-C3 nanoparticle and can be used as a drug delivery system in the treatment of inflammatory and bacterial diseases.

Keywords: Curcumin-C3, curcumin, chitosan, nanoparticle, antioxidant, E. coli, S. aureus.

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Article Details

Year: 2020
Published on: 10 November, 2020
Page: [5021 - 5029]
Pages: 9
DOI: 10.2174/1381612826666200609164830
Price: $65

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