Background: Recent studies have focused on the nanoformulations of curcumin to enhance its solubility
and bioavailability. The medicinal properties of curcumin-C3 complex, which is a combination of three
curcuminoids (curcumin, demethoxycurcumin and bisdemethoxycurcumin) is less explored.
Objective: The aim of this study was to prepare curcumin-C3 encapsulated in chitosan nanoparticles, characterize
and evaluate their antioxidant and antibacterial potential.
Methods: Ionic gelation method was used to prepare curcumin-C3 nanoparticles and was characterized by Fourier
transform infrared spectroscopy, X-ray diffraction, transmission electron microscopy and nanoparticle tracking
analysis. In vitro assays were performed to assess drug release, antioxidant and antibacterial activities.
Results: Curcumin-C3-chitosan nanoparticle showed an increased entrapment efficiency of >90%, drug release
and improved antioxidant potential. Moreover, curcumin-C3-chitosan nanoparticle showed stronger inhibition of
Escherichia coli and Staphylococcus aureus.
Conclusion: Chitosan is a suitable carrier for curcumin-C3 nanoparticle and can be used as a drug delivery system
in the treatment of inflammatory and bacterial diseases.