Background: Genus Erythrina belongs to family Fabaceae, which is widely distributed
in tropical and subtropical areas. It has been used in both traditional herbal medicines and
pharmacological applications. Original research articles and publications on the overview of
alkaloids related to this genus are available, but a supportive systematic review account which
highlighted phytochemical aspects of other types of secondary metabolites is currently insufficient.
Objective: With the utilization of data and information from SCI-Finder, Google Scholar, the Web
of Science, Scopus, Science Direct, PubMed, Chemical Abstracts, ACS journals, Springer, Taylor
Francis, Bentham Science and IOP Science, the reliable material sources of this systematic review
paper were obtained from the literature published from the 1980s to now.
Conclusion: A vast amount of data showed that the non-alkaloidal secondary metabolites were
obtained from genus Erythrina with various classes of chemical structures. Herein, approximately
five hundred constituents were isolated, comprising flavonoids, terpenoids, saponins, phytosterols,
phenols, arylbenzofurans, coumarins, alcohols, ceramides, mono-sugars and fatty acid derivatives.
In agreement with the previous phytochemical reports on the plants of the family Fabaceae,
flavonoids reached a high amount in the plants of genus Erythrina. Numerous biological activity
investigations such as anti-bacteria, anti-cancer, anti-virus using isolated compounds from
Erythrina species suggested that secondary metabolites of Erythrina plants are now becoming the
promising agents for drug developments.