Targeting Protein Degradation in Cancer Treatment

(E-pub Ahead of Print)

Author(s): Imane Bjij, Ismail Hdoufane, Mahmoud Soliman, Menče Najdoska-Bogdanov, Driss Cherqaoui*

Journal Name: Current Chemical Biology

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Abstract:

The ubiquitin proteasome system (UPS) is a crucial protein degradation pathway that involves several enzymes to maintain cellular protein homeostasis. This system has emerged as a major drug target against certain types of cancer as a disruption at the cellular level of UPS enzyme components forces the transformation of normal cell into cancerous cell. Although enormous advancements have been achieved in the understanding of tumorigenesis, efficient cancer therapy remains a goal towards alleviating this serious health issue. Since UPS has become a promising target for anticancer therapies, herein we provide comprehensive review of the ubiquitin proteasome system as a significant process for protein degradation. Herein, the anti-cancer therapeutic potential of this pathway is also discussed.

Keywords: Protein degradation, Cancer therapy, UPS, Proteasome, Mechanism of action, Fragmentation

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/2212796814999200609131623
Price: $95

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