Aims: Adsorption conditions of propranolol hydrochloride onto MCF are optimized. Properties
of this adsorption system are studied. The sustained release properties of propranolol hydrochloride
in the loading system are also researched.
Background: In today's society, demand for drugs is getting higher and higher. With the development
of nanotechnology, it is easier to immobilize drugs on nanomaterials, which can easily transport drugs
in the human body. It can control drug release, reduce side effects, improve drug efficacy, and develop
Objective: The purpose of this study was to load propranolol hydrochloride, a drug for the treatment
of heart disease and hypertension on the MCF nano-mesoporous material to prepare a sustainedrelease
preparation and investigate the release law of propranolol hydrochloride in simulated human
Methods: Nanometer mesoporous MCF (mesocellular foams) silica material was prepared in acidic
medium using triblock copolymer poly(ethylene glycol)-block-poly(propyl glycol)-block-poly(ethylene
glycol) as template and tetraethoxysilane as silica source. Propranolol hydrochloride drug was incorporated
into the MCF mesoporous material by the impregnation method to prepare MCF-propranol
hydrochloride host-guest composite material. The loading amount of drug was calculated by spectrophotometry
and difference subtraction method.
Results: The loading amount of drug calculated by spectrophotometry and difference subtraction
method was 385.5 mg·g-1 (propranolol hydrochloride/MCF). The adsorption process of propranolol
hydrochloride in MCF belongs to the quasi-second-order kinetic process. Adsorption process ΔH0 =
-19.11 kJ·mol-1, is an exothermic process, ΔG0 < 0, the adsorption process is a spontaneous process.
The effective release time of drug lasted up to 32 h and the maximum cumulative released amount was
99.4 % through the experiment of drug sustained release in the simulated body fluid. In the simulated
gastric juice, the release time of drug reached 6 h, and the maximum cumulative released amount was
56.6 %. When drug release time arrived at 10 h in the simulated intestinal fluid, the maximum cumulative
released amount was 71.3 %.
Conclusion: The influence of the release rate of propranolol hydrochloride molecules from MCF
mesopores was demonstrated, since it results in a very slow drug delivery from the nanocomposite
system. Thus, it is concluded that the prepared MCF is an efficient drug sustained-released carrier.