Background: The complex photochemistry of aryl azides has fascinated scientists
for several decades. Spectroscopists have investigated the intermediates formed by
different analytical techniques. Theoretical chemists have explained the intrinsic interplay of
intermediates under different experimental conditions.
Objective & Methods: A complete understanding of the photochemistry of a given fluoro
aryl azide is a basic requisite for its use in chemistry. In this review, we will discuss the
synthesis of several fluoro substituted aryl azides and the reactions and intermediates generated
upon photolysis and thermolysis of these azides and some examples of their applications
in photoaffinity labeling and organic synthesis.
Conclusion: In spite of the extensive research on the photochemistry of fluoro aryl azides, there are some areas
that remain to be investigated. The application of this reaction in the synthesis of novel heterocyclic compounds
has not been fully studied. Since fluorophenyl azides are known to undergo C-H and N-H insertion reactions,
they could be used to prepare new fluorinated molecules or in the biochemical process known as photoaffinity