Backgrounds: It is unknown whether second-generation antipsychotics are safer
than first-generation antipsychotics in terms of seizure induction.
Objective: In the present assessment, the relationships between the incidence of seizure attacks
among a great sample of non-western psychiatric inpatients and prescribed typical
and atypical antipsychotics have been probed and analyzed based on the existing data in
Methods: Razi psychiatric hospital, as one of the largest and oldest public psychiatric hospitals
in the Middle East, had been selected as the field of study in the present retrospective
estimation. For assessment, all inpatients that had suffered a seizure during the last sixtyfour
months had been included in the current study.
Results: Among seventy-four patients who had experienced seizure attack during the inpatient
management, and had been prescribed antipsychotics for symptomatic management of
primary psychiatric disorders, 67.56% had received atypical antipsychotic and the remaining
(32.43%) had received typical antipsychotics, which revealed a significant quantitative
difference between them (p<0.000). Among atypical antipsychotics, olanzapine was the
most recommended antipsychotic (33.78%), followed by risperidone (34%), quetiapine
(9.45%), and clozapine (n=1, 1.35%). Among typical antipsychotics, too, haloperidol
(28.37%) was significantly more prescribed than chlorpromazine (2.70%) and thioridazine
(1.35%) (p<0.000). By the way, there was no significant difference, quantitatively, between
olanzapine and haloperidol in the present evaluation (p<0.47).
Conclusion: Atypical antipsychotics have comparable potentiality, as typical antipsychotics,
for triggering seizure attacks, which demands indispensable cautiousness by clinicians
when prescribing such a group of medications for epileptic and neuropsychiatric patients.