Title:Vitamin D-RAAS Connection: An Integrative Standpoint into Cardiovascular and Neuroinflammatory Disorders
VOLUME: 21 ISSUE: 10
Author(s):Virna Margarita Martín Giménez, Raúl Lelio Sanz, Feres José Mocayar Marón, León Ferder and Walter Manucha*
Affiliation:Instituto de Investigaciones en Ciencias Químicas, Facultad de Ciencias Químicas y Tecnológicas, Universidad Católica de Cuyo, San Juan, Área de Farmacología, Departamento de Patología, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Área de Farmacología, Departamento de Patología, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Department of Pediatrics, Nephrology Division, Miller School of Medicine, University of Miami, Florida, Área de Farmacología, Departamento de Patología, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo
Keywords:Vitamin D, VDR, neuroinflammation, hypertension, renin-angiotensin-aldosterone system, oxidative stress.
Abstract:Background: The neuroinflammatory process is associated with the pathogenesis of many
cardiovascular disorders, particularly with hypertension. In this regard, the deficiency of vitamin D
seems to increase the risk of cardiovascular pathologies related to neuroinflammation. Long-term lack
of vitamin D leads to over-activation of the renin-angiotensin-aldosterone system (RAAS), one of the
essential mechanisms of blood pressure regulation.
Purpose of Review: This review summarizes the latest studies carried out to evaluate the primary
mechanisms underlying the neuroprotective effect of vitamin D and its receptors (VDR) in the central
nervous system. Besides, the present article condenses the evidence supporting the link between vitamin
D and the RAAS in hypertension and neuroinflammation.
Highlights Standpoints: Vitamin D deficiency is highly prevalent in the world, and the rising prevalence
of neuroinflammatory diseases and associated pathologies such as hypertension around the world
justifies the urgent need of searching new and more effective therapeutic methods that could be related
to RAAS modulation and vitamin D levels management.
