Title:An Overview of Excipients Classification and Their Use in Pharmaceuticals
VOLUME: 17 ISSUE: 3
Author(s):Cansel Kose Ozkan*, Ozgur Esim, Ayhan Savaser* and Yalcin Ozkan
Affiliation:Department of Pharmaceutical Technology, Gulhane Faculty of Pharmacy, University of Health Sciences, Gulhane Campus, Etlik, 06018 Ankara, Department of Pharmaceutical Technology, Gulhane Faculty of Pharmacy, University of Health Sciences, Gulhane Campus, Etlik, 06018 Ankara, Department of Pharmaceutical Technology, Gulhane Faculty of Pharmacy, University of Health Sciences, Gulhane Campus, Etlik, 06018 Ankara, Department of Pharmaceutical Technology, Gulhane Faculty of Pharmacy, University of Health Sciences, Gulhane Campus, Etlik, 06018 Ankara
Keywords:Excipients, fillers, surfactants, active pharmaceutical ingredient, incompatibility, excipient toxicity.
Abstract:The content and the application of pharmaceutical dosage forms must meet several basic
requirements to ensure and maintain efficiency, safety and quality. A large number of active substances
have a limited ability to direct administration. Excipients are generally used to overcome the limitation
of direct administration of these active substances. However, the function, behavior and composition of
the excipients need to be well known in the design, development and production of pharmaceutical
dosage forms. In this review, excipients used to assist in any pharmaceutical dosage form production
processes of drugs, to preserve, promote or increase stability, bioavailability and patient compliance, to
assist in product identification/separation, or to enhance overall safety and effectiveness of the drug
delivery system during storage or use are explained. Moreover, the use of these excipients in drug delivery
systems is identified. Excipient toxicity, which is an issue discussed in the light of current studies,
also discussed in this review.
