An Insight Into the Anxiolytic Effects of Lignans (Phyllanthin and Hypophyllanthin) and Tannin (Corilagin) Rich Extracts of Phyllanthus amarus : An In-Silico and In-vivo approaches

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Author(s): Atul R. Chopade*, Rahul P. Pol, Pramod A. Patil, Vyankatesh R. Dharanguttikar, Nilofar S. Naikwade, Remeth J. Dias, Suraj N. Mali

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

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Background: This investigation was aimed to explore the anxiolytic potential of Phyllanthus amarus standardized extracts and predict probable role of marker phyto constitutents.

Objective and Methods: Three standardized extracts of Phyllanthus amarus plant viz. standardized aqueous extract of Phyllanthus amarus whole plant (PAAE), standardized methanolic extract of P. amarus leaf (PAME) and the standardized hydro-methanolic extract of P. amarus leaf (PAHME) were tested in the classical animal models of anxiety vise: Elevated plus-maze model and Light & Dark Exploration test.

Results: The lower doses of the tannin rich extract (PAHME) of the P. amarus possess significant anxiolytic activity compared to lignin rich (PAME) and aqueous extracts (PAAE), while at a higher dose (400mg/kg) the results of all three extracts appears to be potentially sedative. While the molecular docking studies support these probable anxiolytic and sedative effects of the Phyllanthus amarus extracts could be due to the interaction of tannins and lignans with the GABA-benzodiazepine receptor complex.

Conclusion: The results of the present study indicate that the tannin-rich extract of the P. amarus may have potential clinical applications in the management of anxiety. It can be further studied for optimum dosage to be used as a future of anti-anxiety drug development or as a standardized Phytomedicine.

Keywords: Phyllanthus amarus, Anxiety, Phyllanthin, Hypophyllanthin, Corilagin.

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(E-pub Ahead of Print)
DOI: 10.2174/1386207323666200605150915
Price: $95

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