Current Film Coating Designs for Colon-Targeted Oral Delivery

Author(s): Phuong H.L. Tran, Thao T.D. Tran*

Journal Name: Current Medicinal Chemistry

Volume 28 , Issue 10 , 2021


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Abstract:

Colon-targeted oral delivery has recently attracted a substantial number of studies on both systemic and local treatments. Among approaches for colonic delivery, film coatings have been demonstrated as effective elements of the drug delivery systems because they can integrate multiple release strategies, such as pH-controlled release, time-controlled release and enzyme-triggered release. Moreover, coating layer modulations, natural film materials and nanoparticle coatings have been vigorously investigated with promising applications. This review aims to describe the primary approaches for improving drug delivery to the colon in the last decade. The outstanding importance of current developments in film coatings will advance dosage form designs and lead to the development of efficient colon-targeted oral delivery systems.

Keywords: Colonic delivery, film coating, film modulation, natural-based film, nanoparticle coating, drug delivery.

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Article Details

VOLUME: 28
ISSUE: 10
Year: 2021
Published on: 04 June, 2020
Page: [1957 - 1969]
Pages: 13
DOI: 10.2174/0929867327666200604170048
Price: $65

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