Background and Objective: Psoriasis is an autoimmune skin disease involving cascading release
of cytokines activated by the innate and acquired immune system. The increasing prevalence rate of
psoriasis demands for more appropriate therapy. The existing chemical moiety is promising for better
therapeutic outcome, but the selection of a proper channel for administration has to be reviewed. Hence
there is a need to select the most appropriate dosage form and route of administration for improving the
curative rate of psoriasis.
Results: A total of 108 systematic reviews of research and review articles were conducted to make the
manuscript comprehensible. The role of inflammatory mediators in the pathogenesis of the disease is discussed
for a better understanding of the selection of pharmacotherapy. The older and newer therapeutic
moiety with its mode of administration for psoriasis treatment has been discussed. With a comparative
review on topical and oral administration of first-line drugs such as methotrexate (MTX), cyclosporine
(CsA), and betamethasone, its benefits-liabilities in the selected routes were accounted for. Emphasis has
also been paid on advanced nanocarriers for dermatologic applications.
Conclusion: For a better therapeutic outcome, proper selection of drug moiety with its appropriate administration
is the major requisite. With the advent of nanotechnology, the development of nanocarrier for
dermatologic application has been successfully demonstrated in positioning the systemically administrated
drug into topical targeted delivery. In a nutshell, to achieve successful treatment strategies towards psoriasis,
there is a need to focus on the development of stable, non-toxic nanocarrier for topical delivery. Inclusion
of the existing orally administered drug moiety into nanocarriers for topical delivery is proposed in
order to enhance therapeutics payload with reduced side effects which serves as a better treatment approach
for relief of the psoriasis condition.