Background: The cardiac system is a combination of a complex structure, various cells, and versatile specified functions and sophisticated regulatory mechanisms. Moreover, cardiac diseases that encompass a wide range of
endogenous conditions, remain a serious health burden worldwide. Recent genome-wide profiling techniques have taken
the lead in uncovering a new realm of cell types and molecular programs driving physiological and pathological processes in various organs and diseases. In particular, the emerging technique single-cell RNA sequencing dominates a
breakthrough in decoding the cell heterogeneity, phenotype transition, and developmental dynamics in cardiovascular
Conclusion: Herein, we review recent advances in single cellular studies of cardiovascular system and summarize new
insights provided by single-cell RNA sequencing in heart developmental sciences, stem-cell researches as well as normal or disease-related working mechanisms.