Single-cell RNA Sequencing: In-depth Decoding of Heart Biology and Cardiovascular Diseases

Author(s): Zhongli Chen, Liang Wei, Firat Duru, Liang Chen*

Journal Name: Current Genomics

Volume 21 , Issue 8 , 2020


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Abstract:

Background: The cardiac system is a combination of a complex structure, various cells, and versatile specified functions and sophisticated regulatory mechanisms. Moreover, cardiac diseases that encompass a wide range of endogenous conditions, remain a serious health burden worldwide. Recent genome-wide profiling techniques have taken the lead in uncovering a new realm of cell types and molecular programs driving physiological and pathological processes in various organs and diseases. In particular, the emerging technique single-cell RNA sequencing dominates a breakthrough in decoding the cell heterogeneity, phenotype transition, and developmental dynamics in cardiovascular science.

Conclusion: Herein, we review recent advances in single cellular studies of cardiovascular system and summarize new insights provided by single-cell RNA sequencing in heart developmental sciences, stem-cell researches as well as normal or disease-related working mechanisms.

Keywords: Singe-cell RNA sequencing, cardiovascular disease, cardiogenesis, stem cells, vascular system, heart transcriptome.

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Article Details

VOLUME: 21
ISSUE: 8
Year: 2020
Published on: 21 December, 2020
Page: [585 - 601]
Pages: 17
DOI: 10.2174/1389202921999200604123914
Price: $65

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