Metals Linked to Alzheimer's Disease
Pp. 213-235 (23)
Hani Nasser Abdelhamid
Exposure to metals including copper, zinc, aluminum, and iron ions occurs
inevitably. Any disturbance in metal homeostasis develops diseases and abnormalities.
Metal ions undergo an electric charge balance via gaining or losing electrons from
surrounded biomolecules. They bind to amyloid fibrils or tau proteins in the brain in a
way that links to the development of neurodegenerative diseases including Alzheimer's
disease (AD). For several decades, scientists have been exploring possible links
between metals imbalance and AD. However, very little is known about the exact
mechanisms governing the links of metals to AD. This book chapter summarizes recent
thoughts in the research studies that focus on the links between metals and AD. Most of
the current results suggested that metal binding to amyloid binds affects the
architecture of the protein fibrils and rate of propagation.
Alzheimer's disease, Bioinorganic, Metals, Neurodegenerative
Advanced Multifunctional Materials Laboratory, Department of Chemistry, Assiut University, Assiut 71516, Egypt