Mesenchymal Stem Cell-Based Therapy for COVID-19: Possibility and Potential

Author(s): Jing Xiong, Lei Bao, Hongbo Qi, Zhichun Feng*, Yuan Shi*

Journal Name: Current Stem Cell Research & Therapy

Volume 16 , Issue 2 , 2021

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Abstract:

A novel coronavirus, named severe acute respiratory syndrome coronavirus 2 (SARS-CoV- 2) has emerged in Wuhan, China since the end of December 2019 and has quickly spread all over the world in a matter of two months. To date, no specific treatment has been proven to be effective for coronavirus (COVID-19). With the rapid increase of infected patients and deaths, it is vital to explore an effective treatment for COVID-19. Current studies suggest that there exists cytokine storm in SARS-CoV-2-infected patients; some of the them will develop acute respiratory distress syndrome (ARDS) and multiple organ dysfunction, and even death. Mesenchymal stem cells (MSCs) possess the property of immunomodulation. Given the previous preclinical and clinical studies, MSCs therapy has shown safety and efficacy in the treatment of respiratory failure or ARDS. Based on similar principles, MSCs therapy may also be an effective therapy in the treatment of COVID-19. In this study, we summarized the clinical outcomes of MSCs for ARDS patients in some preclinical and clinical studies and discussed the application of MSCs for patients with COVID-19 in China and the related important issues with MSCs used during the outbreak.

Keywords: Mesenchymal stem cells, coronavirus disease 2019, acute respiratory distress syndrome, dysfunction, cytokine, syndrome.

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Article Details

VOLUME: 16
ISSUE: 2
Year: 2021
Page: [185 - 188]
Pages: 4
DOI: 10.2174/1574888X15666200601152832
Price: $95

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