New Approaches for the Treatment of Mental Disorders Comorbid with Inflammatory Diseases

Author(s): Hande Sipahi*, Eva Reininghaus

Journal Name: Current Topics in Medicinal Chemistry

Volume 20 , Issue 15 , 2020

Become EABM
Become Reviewer

WHO. Mental Health Action Plan, 2013-2020. Available from:.;jsessionid=A7783D9D3678C625FBA1747068347071?sequence=1 (Accessed on April 23rd;2020)
WHO. Mental disorder. Available from:. on April 23rd;2020)
Yuan, N.; Chen, Y.; Xia, Y.; Dai, J.; Liu, C. Inflammation-related biomarkers in major psychiatric disorders: a cross-disorder assessment of reproducibility and specificity in 43 meta-analyses. Translational. Psychiatry, 2019, 9(1), 233.
Reininghaus, B.; Riedrich, K.; Dalkner, N.; Lehner, L.A.; Rieger, A.; Hamm, C.; Dorn, M.; Gradauer, L.; Hufnagl, A.; Mayr-Mauhart, M.; Miniberger, G.; Schachner, A.; Wagger, K.; Birner, A.; Platzer, M.; Fellendorf, F.; Queissner, R.; Bengesser, S.; Reininghaus, E. Physical health in individuals with psychiatric disorders in Austria. J. Affect. Disord., 2019, 257, 38-44.
Halaris, A. Inflammation-associated co-morbidity between depression and cardiovascular disease. Curr. Top. Behav. Neurosci., 2017, 31, 45-70.
Reininghaus, E.Z.; McIntyre, R.S.; Reininghaus, B.; Geisler, S.; Bengesser, S.A.; Lackner, N.; Hecht, K.; Birner, A.; Kattnig, F.; Unterweger, R.; Kapfhammer, H.P.; Zelzer, S.; Fuchs, D.; Mangge, H. Tryptophan breakdown is increased in euthymic overweight individuals with bipolar disorder: a preliminary report. Bipolar Disord., 2014, 16(4), 432-440.
Bauer, I.E.; Green, C.; Colpo, G.D.; Teixeira, A.L.; Selvaraj, S.; Durkin, K.; Zunta-Soares, G.B.; Soares, J.C. A double-blind, randomized, placebocontrolled study of aspirin and n-acetylcysteine as adjunctive treatments for bipolar depression. J. Clin. Psych., 2018, 80(1) , 18m12200
Köhler-Forsberg, O.; N Lydholm, C.; Hjorthøj, C.; Nordentoft, M.; Mors, O.; Benros, M.E. Efficacy of anti-inflammatory treatment on major depressive disorder or depressive symptoms: meta-analysis of clinical trials. Acta Psychiatr. Scand., 2019, 139(5), 404-419.
Decourt, B.; Lahiri, D.K.; Sabbagh, M.N. Targeting tumor necrosis factor alpha for alzheimer’s disease. Curr. Alzheimer Res., 2017, 14(4), 412-425.
Bayram, F.E.Ö.; Reis, R.; Tunçer, B.; Sipahi, H. The importance of the structural similarity of drugs used for depression and inflammation, two comorbid diseases. Curr. Top. Med. Chem., 2018, 18(16), 1416-1421.
Önen Bayram, F.E.; Alradhwani, S.A.A.; Tugcu, G.; Sipahi, H. Do we build similar molecules for comorbid diseases? tevarud in drug design, an analysis for depression and inflammation. ACS Med. Chem. Lett., 2020, 11(2), 147-153.
Sipahi, H.; Kadıoğlu, B.; Bayram, F.E.Ö. Discovery of new medication for the treatment of depression comorbid with inflammatory diseases. Curr. Top. Med. Chem., 2018, 18(16), 1393-1394.
Sekeroglu, H.T.; Sekeroglu, M.A. Ocular inflammation and depression: ophthalmologists’ perspective. Curr. Top. Med. Chem., 2019, 18(16), 1402-1407.
Varan, Ö.; Babaoğlu, H.; Göker, B. Associations between depressive disorders and inflammatory rheumatic diseases. Curr. Top. Med. Chem., 2018, 18(16), 1395-1401.
Geisler, S.; Sperner-Unterweger, B.; Fuchs, D.; Gostner, J.M. Immunometabolism in the pathogenesis of depressive disorders - therapeutic considerations. Curr. Top. Med. Chem., 2018, 18(16), 1408-1415.
Maget, A.; Platzer, M.; Bengesser, S.A.; Fellendorf, F.T.; Birner, A.; Queissner, R.; Hamm, C.; Reininghaus, B.; Hecker, A.; Tomberger, L.; Pilz, R.; Dalkner, N.; Moll, N.; Schütze, G.; Schwarz, M.; Kapfhammer, H.P.; Reininghaus, E.Z. Differences in kynurenine metabolism during depressive, manic, and euthymic phases of bipolar affective disorder. Curr. Top. Med. Chem., 2020, 20(15), 1344-1352.
Wadhawan, A.; Reynolds, M.A.; Makkar, H.; Scott, A.J.; Potocki, E.; Hoisington, A.J.; Brenner, L.A.; Dagdag, A.; Lowry, C.A.; Dwivedi, Y.; Postolache, T.T. Periodontal pathogens and neuropsychiatric health. Curr. Top. Med. Chem., 2020, 20(15), 1353-1397.
Lowe, D.J.E.; Müller, D.J.; George, T.P. Ketamine treatment in depression: a systematic review of clinical characteristics predicting symptom improvement. Curr. Top. Med. Chem., 2020, 20(15), 1398-1414.
Leblhuber, F.; Steiner, K.; Geisler, S. Dietmar Fuchs, Gostner, J.M. On the possible relevance of bottom-up pathways in the pathogenesis of Alzheimer’s dementia. Curr. Top. Med. Chem., 2020, 20(15), 1415-1421.

promotion: free to download

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2020
Published on: 01 June, 2020
Page: [1342 - 1343]
Pages: 2
DOI: 10.2174/156802662015200601093328

Article Metrics

PDF: 23