Alzheimer's disease (AD) is a chronic neurodegenerative disorder that is marked by cognitive dysfunctions
and the existence of neuropathological hallmarks such as amyloid plaques, and neurofibrillary tangles. It has
been observed that a persistent immune response in the brain has appeared as another neuropathological hallmark
in AD. The sustained activation of the microglia, the brain’s resident macrophages, and other immune cells has
been shown to aggravate both tau and amyloid pathology and may consider as a connection in the AD pathogenesis.
However, the basic mechanisms that link immune responses in the pathogenesis of AD are unclear until now
since the process of neuroinflammation can have either a harmful or favorable effect on AD, according to the
phase of the disease. Numerous researches recommend that nutritional fruits, as well as vegetables, possess neurodefensive
properties against the detrimental effects of neuroinflammation and aging. Moreover, these effects
are controlled by diverse phytochemical compounds that are found in plants and demonstrate anti-inflammatory,
neuroprotective, as well as other beneficial actions. In this review, we focus on the link of neuroinflammation in
AD as well as highlight the probable mechanisms of alkaloidal phytochemicals to combat the neuroinflammatory
aspect of AD.